Wine headaches, hangovers and sulphite sensitivity are often discussed together. Understanding the differences helps put the research behind Clean Wine in context.
Sulphites in wine
Sulphites are used as preservatives and can also occur naturally during winemaking. Clean Wine is a spray designed to reduce sulphites in wine before it is consumed. Sulphite reduction is a different question from whether a product prevents every cause of a hangover.
What did the 2019 headache study find?
Silva and colleagues studied 80 volunteers aged 18–25 using a double-blind crossover comparison of white wines with different sulphite concentrations. A subgroup of 51 participants reported previous wine-related headaches.
In that subgroup, the reported odds ratio for headache after the higher-sulphite wine was 2.266 (approximately 2.27), compared with the lower-sulphite wine. The 95% confidence interval was 1.002–5.125.
The study investigated sulphite concentrations and headaches. It did not test Clean Wine itself, and its results should not be described as a clinical trial proving that this product eliminates hangovers.
Wine headaches and hangovers
Alcohol-related hangovers can involve several processes. Sulphite sensitivity is not the same as a hangover, and reducing sulphites does not remove alcohol from wine or make excessive drinking safe. Individual experiences can differ.
For general information on alcohol and hangovers, see the NIAAA hangover factsheet. If you have asthma, a known sensitivity or recurrent symptoms after wine, seek advice from a qualified healthcare professional rather than relying on a wine treatment to make it safe for you.
Research and customer experience
Customer reviews describe individual experiences. They can help you understand how people use Clean Wine, but they are separate from controlled scientific evidence.
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Reviewed by the Clean Wine website team on 26 September 2026. This page explains the cited research; it is not personalised medical advice.